Pfn1^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Pfn1^tm1Ref
• Name: profilin 1; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:3843221
• Synonyms: pfn1^fl, Pfn1^flx
• Gene: Pfn1 Location: Chr11:70542676-70545470 bp, - strand Genetic Position: Chr11, 43.21 cM, cytoband A-D
• Alliance: Pfn1^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148004
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo-tk cassette was inserted upstream of the promoter region and exon 1 and a third loxP site was inserted after exon 1 via homologous recombination. (J:148004)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pfn1 Mutation: 12 strains or lines available

References

• Original: J:148004 Bottcher RT, et al., Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J. 2009 Apr 22;28(8):1157-69
• All: 14 reference(s)