Septin12^tm1.1Plk
Targeted Allele Detail

Summary

• Symbol: Septin12^tm1.1Plk
• Name: septin 12; targeted mutation 1.1, Pao-Lin Kuo
• MGI ID: MGI:3843373
• Gene: Septin12 Location: Chr16:4804722-4815716 bp, - strand Genetic Position: Chr16, 2.49 cM, cytoband A1
• Alliance: Septin12^tm1.1Plk page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:147965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted downstream of exon 2, and an additional loxP site was inserted downstream of exon 7. Transient cre expression in ES cells removed exons 3 through 7 along with the neo cassette. (J:147965)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin12 Mutation: 25 strains or lines available

Notes

Chimeric male mice are sterile.

References

• Original: J:147965 Lin YH, et al., The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009 May;174(5):1857-68
• All: 1 reference(s)