Lat^tm1.1Wz
Targeted Allele Detail

Summary

• Symbol: Lat^tm1.1Wz
• Name: linker for activation of T cells; targeted mutation 1.1, Weiguo Zhang
• MGI ID: MGI:3843455
• Synonyms: LAT^f
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm1.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147946
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 6, and exons 7 through 11 were replaced with the corresponding cDNA and an frt flanked neo cassette with a 3' loxP site followed by an GFP gene. Germ line, flp mediated recombination remove the neo cassette. Expression of the EGFP gene can only be achieved through cre mediated removal of the cDNA encoding exons 7 through 11. (J:147946)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 10 strains or lines available

References

• Original: J:147946 Shen S, et al., The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol. 2009 May 1;182(9):5596-604
• All: 8 reference(s)