Avp^tm1Hari
Targeted Allele Detail

Summary

• Symbol: Avp^tm1Hari
• Name: arginine vasopressin; targeted mutation 1, Hiroshi Arima
• MGI ID: MGI:3843456
• Synonyms: FNDI
• Gene: Avp Location: Chr2:130422540-130424474 bp, - strand Genetic Position: Chr2, 63.24 cM
• Alliance: Avp^tm1Hari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147993
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed pgk-neo cassette was inserted in intron 2 and a Cys98stop nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. Immunohistochemical analysis detected expression of a mutant protein in the supraoptic nucleus, the suprachiasmatic nuclei, and the paraventricular nucleus in homozygous and heterozygous mice. This analysis also confirmed the absence of wild-type protein expression in homozygous mice. (J:147993)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avp Mutation: 19 strains or lines available

References

• Original: J:147993 Hayashi M, et al., Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1641-9
• All: 5 reference(s)