Avp^tm1Lja
Targeted Allele Detail

Summary

• Symbol: Avp^tm1Lja
• Name: arginine vasopressin; targeted mutation 1, J Larry Jameson
• MGI ID: MGI:3843457
• Synonyms: Avp^C67X
• Gene: Avp Location: Chr2:130422540-130424474 bp, - strand Genetic Position: Chr2, 63.24 cM
• Alliance: Avp^tm1Lja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148012
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted in intron 1 and a C67X nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. RT-PCR confirmed the expression of mutant transcript in the hypothalamus. (J:148012)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avp Mutation: 19 strains or lines available

References

• Original: J:148012 Russell TA, et al., A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons. J Clin Invest. 2003 Dec;112(11):1697-706
• All: 1 reference(s)