Tg(Thy1-UBB*)8630Fwvl
Transgene Detail

Summary

• Symbol: Tg(Thy1-UBB*)8630Fwvl
• Name: transgene insertion 8630, FW van Leeuwen
• MGI ID: MGI:3843489
• Synonyms: Ubb+1 8630
• Transgene: Tg(Thy1-UBB*)8630Fwvl Location: unknown
• Alliance: Tg(Thy1-UBB*)8630Fwvl page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-UBB*)8630Fwvl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  UBB (7314)

  Ubb	(MGI:98888)

• Mutation details: A transgenic construct containing cDNA encoding the mutant human ubiquitin B, UBB+1 sequence (in the +1 reading frame), under the direction of the mouse Thy1.2 promoter was injected into fertilized FVB/N mouse eggs. Founder line 8630 with 2 copies of the transgene was subsequently established. mRNA levels for UBB+1 are 67% of endogenous Ubb mRNA levels. (J:147938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:147938 Fischer DF, et al., Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiol Aging. 2009 Jun;30(6):847-63
• All: 1 reference(s)