Tg(Drd1a-cre/ERT2)61.3Gsc
Transgene Detail

Summary

• Symbol: Tg(Drd1a-cre/ERT2)61.3Gsc
• Name: transgene insertion 61.3, Gunther Schutz
• MGI ID: MGI:3843500
• Synonyms: D1Cre-ERT2, D1CreERT2, D1Cre-ERT2 BAC transgene, D1Cre-ERT2 line 61.3
• Transgene: Tg(Drd1a-cre/ERT2)61.3Gsc Location: unknown
• Alliance: Tg(Drd1a-cre/ERT2)61.3Gsc page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Drd1a-cre/ERT2)61.3Gsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Drd1 (MGI:99578)

• Mutation details: The bacterial artificial chromosome (BAC) RP24-179E13 containing the entire dopamine D1 receptor (Drd1a) gene (and incomplete Sfxn1 gene) was altered to insert a cre/ERT2 fusion gene, replacing the ATG of Drd1a ATG with the cre/ERT2 replace. This modified BAC was microinjected into the pronucleus of C57BL/6N oocytes. D1Cre-ERT2 founder mice (line 61.3) were established and found to have approximately 4 copies of the transgene. Cre recombinase expression is observed in the major projections areas of the dopaminergic system (including nucleus accumbens and striatum), while weaker expression is observed in specific regions of the cortex and thalamus, and in scattered regions of the hippocampus. (J:148084, J:156916)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Drd1 (mouse) Summary of all recombinase alleles driven by Drd1. Alliance mouse Drd1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:148084 Schutz G, Generation of a tamoxifen-inducible cre transgene under control of the Drd1a promoter. MGI Direct Data Submission. 2009
• All: 9 reference(s)