Myh9^tm1.1Gac
Targeted Allele Detail

Summary

• Symbol: Myh9^tm1.1Gac
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Christian Gachet
• MGI ID: MGI:3843980
• Synonyms: Myh9flox, MYH9^Flx
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^tm1.1Gac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148233
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and a floxed neo cassette was inserted downstream of exon 1. Transient expression in ES cells removed the neo cassette leaving exon 1 floxed. (J:148233)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 219 strains or lines available

References

• Original: J:148233 Leon C, et al., Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood. 2007 Nov 1;110(9):3183-91
• All: 19 reference(s)