Map3k6^tm1Hijo
Targeted Allele Detail

Summary

• Symbol: Map3k6^tm1Hijo
• Name: mitogen-activated protein kinase kinase kinase 6; targeted mutation 1, Hidenori Ichijo
• MGI ID: MGI:3843985
• Gene: Map3k6 Location: Chr4:132968129-132980240 bp, + strand Genetic Position: Chr4, 66.25 cM
• Alliance: Map3k6^tm1Hijo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148044
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ cassette with a nuclear localization signal and a reverse orientation pgk-neo cassette replaced exons 1 - 5 via homologous recombination. Immunoblot analysis of homozygous MEFs and primary keratinocytes confirmed the absence of protein expression. (J:148044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Map3k6 Mutation: 56 strains or lines available

References

• Original: J:148044 Iriyama T, et al., ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J. 2009 Apr 8;28(7):843-53
• All: 5 reference(s)