Pxmp2^tm1Jkh
Targeted Allele Detail

Summary

• Symbol: Pxmp2^tm1Jkh
• Name: peroxisomal membrane protein 2; targeted mutation 1, J Kalervo Hiltunen
• MGI ID: MGI:3844254
• Gene: Pxmp2 Location: Chr5:110422152-110434036 bp, - strand Genetic Position: Chr5, 53.44 cM
• Alliance: Pxmp2^tm1Jkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148171
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A lacZ cassette and neo cassette in inverse orientation were inserted into exon 2 via homologous recombination. Northern blot and quantitative RT-PCR confirmed the absence of RNA expression. Immunoblot analysis confirmed the absence of protein expression in livers from homozygous mice. (J:148171)

Generation of the Pxmp2^tm1Jkh allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pxmp2 Mutation: 12 strains or lines available

References

• Original: J:148171 Rokka A, et al., Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane. PLoS One. 2009;4(4):e5090
• All: 2 reference(s)