Ank1^Rbc2
Chemically induced Allele Detail

Summary

• Symbol: Ank1^Rbc2
• Name: ankyrin 1, erythroid; red blood cell mutant 2
• MGI ID: MGI:3844284
• Synonyms: Ank-1¹⁶⁷⁴
• Gene: Ank1 Location: Chr8:23464860-23640513 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Ank1^Rbc2 page

Mutation origin

• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺ or BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU treatment of male mice with Mpl^tm1Wsa on a BALB/c background induced a G to C transversion located at the splice acceptor site of exon 41. This point mutation induces a frame shift after amino acid 1674 and results in the addition of 96 residues and a premature codon. (J:148127)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank1 Mutation: 106 strains or lines available

References

• Original: J:148127 Rank G, et al., Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood. 2009 Apr 2;113(14):3352-62
• All: 2 reference(s)