Tg(Thy1-Nlgn2)6Hnes
Transgene Detail

Summary

• Symbol: Tg(Thy1-Nlgn2)6Hnes
• Name: transgene insertion 6, Rochelle Hines
• MGI ID: MGI:3844455
• Synonyms: TgNL2.6
• Transgene: Tg(Thy1-Nlgn2)6Hnes Location: unknown
• Alliance: Tg(Thy1-Nlgn2)6Hnes page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Nlgn2)6Hnes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nlgn2 (MGI:2681835)

• Mutation details: The TgNL2 transgene was designed with a modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) upstream of a hemagglutinin-tagged rat neuroligin 2 (Nlgn2 or NL2) cDNA. Transgenic founders were bred with C57BL/6 and mice from founder line 6 (TgNL2.6) were found to have an approximately 1.6-fold increase in NL2 expression and moderate phenotype severity, (J:137376)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:137376 Hines RM, et al., Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008 Jun 11;28(24):6055-67
• All: 1 reference(s)