Tg(Thy1-Nlgn1)6Hnes
Transgene Detail

Summary

• Symbol: Tg(Thy1-Nlgn1)6Hnes
• Name: transgene insertion 6, Rochelle Hines
• MGI ID: MGI:3844457
• Synonyms: TgNL1, TgNL1.6
• Transgene: Tg(Thy1-Nlgn1)6Hnes Location: unknown
• Alliance: Tg(Thy1-Nlgn1)6Hnes page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Nlgn1)6Hnes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nlgn1 (MGI:2179435)

• Mutation details: The TgNL1 transgene was designed with a modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) upstream of a hemagglutinin-tagged mouse neuroligin 1 (Nlgn1 or NL1) cDNA. This transgene was injected into (C57BL/6xCBA)F1 cells. Transgenic founders were bred with C57BL/6 and mice from founder line 6 (TgNL1.6) were found to have approximately two-fold increase in NL1 expression. (J:137376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:137376 Hines RM, et al., Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008 Jun 11;28(24):6055-67
• All: 1 reference(s)