Htr6^tm1Tct
Targeted Allele Detail

Summary

• Symbol: Htr6^tm1Tct
• Name: 5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1, Laurence H Tercott
• MGI ID: MGI:3844587
• Gene: Htr6 Location: Chr4:138788419-138802881 bp, - strand Genetic Position: Chr4, 70.57 cM
• Alliance: Htr6^tm1Tct page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148381
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 300 bp fragment of exon 1 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of wild-type transcript in brains from homozygous mice. (J:148381)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr6 Mutation: 27 strains or lines available

References

• Original: J:148381 Bonasera SJ, et al., A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology. 2006 Aug;31(8):1801-13
• All: 3 reference(s)