Khdc3^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Khdc3^tm1Dean
• Name: KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:3844604
• Synonyms: Filia^tm
• Gene: Khdc3 Location: Chr9:73009118-73011720 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Khdc3^tm1Dean page

Impaired preimplantation development of Khdc3^tm1Dean/Khdc3^tm1Dean embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The first 2 exons including the transcription and translation start sites and part of the 5' UTR were replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in ovaries from homozygous mice. (J:148330)

Generation of the Khdc3^tm1Dean allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Khdc3 Mutation: 15 strains or lines available

References

• Original: J:148330 Zheng P, et al., Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7473-8
• All: 3 reference(s)