Ptgs2^tm1Gaf
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Gaf
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Garret A FitzGerald
• MGI ID: MGI:3844713
• Synonyms: CM-COX-2, COX-2^flox
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Gaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 6, 7, and 8 that are critical for enzymatic function were flanked by loxP sites. PGE-2 production by activated peritoneal macrophages is unaffected in mice homozygous for this allele, indicating that gene function was not disrupted. (J:148331)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:148331 Wang D, et al., Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52
• All: 17 reference(s)