Extl3^tm1.1Okam
Targeted Allele Detail

Summary

• Symbol: Extl3^tm1.1Okam
• Name: exostosin-like glycosyltransferase 3; targeted mutation 1.1, Hiroshi Okamoto
• MGI ID: MGI:3844734
• Synonyms: Extl3^-
• Gene: Extl3 Location: Chr14:65289509-65387304 bp, - strand Genetic Position: Chr14, 33.86 cM, cytoband D1
• Alliance: Extl3^tm1.1Okam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148348
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination of Extl3^tm1Okam removed exon 2 and the neo cassette. HPLC analysis confirmed the absence of heparan sulfate derived disaccharides in homozygous embryos. (J:148348)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Extl3 Mutation: 37 strains or lines available

References

• Original: J:148348 Takahashi I, et al., Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun. 2009 May 22;383(1):113-8
• All: 1 reference(s)