Tg(KRT5-Nfkbia*)3Rto
Transgene Detail

Summary

• Symbol: Tg(KRT5-Nfkbia*)3Rto
• Name: transgene insertion 3, Rune Toftgard
• MGI ID: MGI:3844945
• Synonyms: K5-IkappaBalphaSR
• Transgene: Tg(KRT5-Nfkbia*)3Rto Location: unknown
• Alliance: Tg(KRT5-Nfkbia*)3Rto page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The bovine promoter was used to drive epidermis-specific expression of a mutated cDNA with nucleotide substitutions leading to amino acid substitutions of glycine for serine at positions 32 and alanine for serine at position 36. These mutations create a super-repressor version that is resistant to phosphorylation and degradation. Seven founders were created and line 3 was selected as the representative line. (J:148457)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-Nfkbia*)3Rto

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:148457 van Hogerlinden M, et al., Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling. Cancer Res. 1999 Jul 15;59(14):3299-303
• All: 5 reference(s)