Mapt^{tm2(Hdac1)Jae}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm2(Hdac1)Jae}
• Name: microtubule-associated protein tau; targeted mutation 2, Rudolf Jaenisch
• MGI ID: MGI:3844981
• Synonyms: HDAC1OE, Tau^HDAC1
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm2(Hdac1)Jae} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148391
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mapt^{tm2(Hdac1)Jae} expresses 2 genes
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hdac1 (MGI:108086)
  mouse	Hdac2 (MGI:1097691)

• Mutation details: Coding sequence for the mouse Hdac1 protein was placed in-frame with exon 1 of the gene locus creating a fusion protein containing the first 31 amino-acids of the endogenous locus. A 2-3 fold increase in expression of Hdac1 was confirmed in the CA1 region of the hippocampus by immunohistofluorescence. Hdac1 activity was confirmed by decreased levels of acetylation present in the same region as expression. (J:148391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:148391 Guan JS, et al., HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 7;459(7243):55-60
• All: 1 reference(s)