Hdac2^tm1.2Rdp
Targeted Allele Detail

Summary

• Symbol: Hdac2^tm1.2Rdp
• Name: histone deacetylase 2; targeted mutation 1.2, Ronald DePinho
• MGI ID: MGI:3844984
• Synonyms: HDAC2KO
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^tm1.2Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148391
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted upstream of exon 5 and downstream of exon 6. Mice carrying this allele were crossed with mice expressing cre recombinase in the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote brain extracts. The same analysis showed that expression of related Hdac1 protein was upregulated. (J:148391)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 40 strains or lines available

References

• Original: J:148391 Guan JS, et al., HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 7;459(7243):55-60
• All: 3 reference(s)