Six2^{tm2(cre/ERT2)Amc}
Targeted Allele Detail

Summary

• Symbol: Six2^{tm2(cre/ERT2)Amc}
• Name: sine oculis-related homeobox 2; targeted mutation 2, Andrew P McMahon
• MGI ID: MGI:3845219
• Synonyms: Six2-CE, Six2^CE, Six2-CreERT, Six2-CreER^T2, Six2^CreERT2
• Gene: Six2 Location: Chr17:85991705-85995702 bp, - strand Genetic Position: Chr17, 55.72 cM
• Alliance: Six2^{tm2(cre/ERT2)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148455
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Six2^{tm2(cre/ERT2)Amc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Six2 (MGI:102778)

• Mutation details: A targeting vector was designed to insert a CreERT2 fusion protein coding sequence and frt-flanked PGKneobpA selection cassette into the initiation codon of the Six2 (sine oculis-related homeobox 2 homolog (Drosophila)) targeted gene. (J:148455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Six2 (mouse) Summary of all recombinase alleles driven by Six2. Alliance mouse Six2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Six2 Mutation: 16 strains or lines available

References

• Original: J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
• All: 9 reference(s)