Rho^Tvrm4
Chemically induced Allele Detail

Summary

• Symbol: Rho^Tvrm4
• Name: rhodopsin; translational research vision model 4
• MGI ID: MGI:3845397
• Synonyms: I307N Rho
• Gene: Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
• Alliance: Rho^Tvrm4 page

Light-induced degeneration of photoreceptors in Rho^Tvrm4/Rho⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (129S4/SvJae x C57BL/6J)F1

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: A missense mutation changes amino acid 307, isoleucine (ATC), to asparagine (AAC). Ile-307 is located in the 7th transmembrane region of RHO and is conserved across species, including human, primate, cat, dog, and rat. (J:159523)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rho Mutation: 51 strains or lines available

References

• Original: J:159523 Budzynski E, et al., Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 7;285(19):14521-33
• All: 7 reference(s)