Wnt4^{tm2(EGFP/cre/ERT2)Amc}
Targeted Allele Detail

Summary

• Symbol: Wnt4^{tm2(EGFP/cre/ERT2)Amc}
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 2, Andrew P McMahon
• MGI ID: MGI:3845544
• Synonyms: Wnt4^-, Wnt4-GCE, Wnt4^GCE
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^{tm2(EGFP/cre/ERT2)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Wnt4^{tm2(EGFP/cre/ERT2)Amc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Wnt4 (MGI:98957)

• Mutation details: The targeting vector was designed to insert an eGFPCreERT2 (GCE) fusion protein-coding sequence and frt-flanked PGKneobpA selection cassette into the initiation codon of the Wnt4 gene in the BAC clone RPCl-23-246F18. (J:148455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wnt4 (mouse) Summary of all recombinase alleles driven by Wnt4. Alliance mouse Wnt4 gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
• All: 10 reference(s)