Pkd1^tm1.2Bol
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1.2Bol
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1.2, Alessandra Boletta
• MGI ID: MGI:3846085
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1.2Bol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Allele was created from Pkd1^tm1.1Bol homozygous mice using ubiquitous Cre expression to delete loxP sites flanked intron 43 and the 3' untranslated region of the gene. (J:148419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:148419 Distefano G, et al., Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol. 2009 May;29(9):2359-71
• All: 1 reference(s)