Hmox1^tm1.2Gkl
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1.2Gkl
• Name: heme oxygenase 1; targeted mutation 1.2, George Kollias
• MGI ID: MGI:3846093
• Synonyms: Hmox1^D, HO-1^KO
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1.2Gkl page

Chronic inflammatory disease in Hmox1^tm1.2Gkl/Hmox1^tm1.2Gkl mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148498
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination was used to remove exon 2 through 4. The absence of protein expression was confirmed by western blot analysis on thioglycollate-stimulated peritoneal macrophage. (J:148498)

Generation of Hmox1^tm1.1Gkl and Hmox1^tm1.2Gkl alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 35 strains or lines available

Notes

ES cell line = "129/3."

References

• Original: J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
• All: 1 reference(s)