Rffltm1Cota
Targeted Allele Detail
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Symbol: |
Rffltm1Cota |
Name: |
ring finger and FYVE like domain containing protein; targeted mutation 1, Michel Cohen-Tannoudji |
MGI ID: |
MGI:3846097 |
Synonyms: |
Rififylin/Carp2 knockout |
Gene: |
Rffl Location: Chr11:82694645-82762065 bp, - strand Genetic Position: Chr11, 50.25 cM, cytoband B5
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Alliance: |
Rffltm1Cota page
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Germline Transmission: |
Earliest citation of germline transmission:
J:148682
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Parent Cell Line: |
CK35 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The first coding exon of the gene is interrupted by a Betageo (beta-galactosidase/neomycin resistance fusion gene) reporter/selection cassette, resulting in the in-frame joining of the Betageo coding sequence to the mouse genomic sequence encoding the first 14 amino acids of the endogenous protein. Whereas wild-type mouse embryonic fibroblasts (MEFs) express RFFL mRNA at levels easily detected by RT-PCR analysis, MEFs from embryos homozygous for this mutation produce no detectable transcript.
(J:148682)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:148682 Ahmed AU, et al., CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha. Curr Biol. 2009 Jan 13;19(1):R15-7; author reply R17-9 |
All: |
1 reference(s) |
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