Nelfb^tm1.1Roli
Targeted Allele Detail

Summary

• Symbol: Nelfb^tm1.1Roli
• Name: negative elongation factor complex member B; targeted mutation 1.1, Rong Li
• MGI ID: MGI:3846130
• Synonyms: Cobra1^fl
• Gene: Nelfb Location: Chr2:25089724-25101501 bp, - strand Genetic Position: Chr2, 17.06 cM
• Alliance: Nelfb^tm1.1Roli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148508
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A frt- and neo-flanked neo cassette was inserted upstream of exon 1, and an additional loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination removed the neo cassette leaving exons 1 through 4 floxed. (J:148508)

Generation of the Nelfb^tm1.1Roli and Nelfb^tm1.2Roli alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nelfb Mutation: 24 strains or lines available

References

• Original: J:148508 Amleh A, et al., Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One. 2009;4(4):e5034
• All: 8 reference(s)