Cisd2^tm1Tfts
Targeted Allele Detail

Summary

• Symbol: Cisd2^tm1Tfts
• Name: CDGSH iron sulfur domain 2; targeted mutation 1, Ting-Fen Tsai
• MGI ID: MGI:3846404
• Gene: Cisd2 Location: Chr3:135112173-135129194 bp, - strand Genetic Position: Chr3, 62.55 cM, cytoband H2
• Alliance: Cisd2^tm1Tfts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148467
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Cisd2^tm1Tfts involves 1 genes/genome features (Cisd2) View all
• Mutation details: The genomic sequence extending from the 3' end of intron 1 through the 5' end of exon 3 was replaced with the missing portion of intron 1 through the 5' end of exon 3 following by a puromycin resistance cassette, loxP site, 3'Hprt mini-gene, and a duplication of the 3' end of intron 1 through the 5' end of exon 3. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:148467)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cisd2 Mutation: 36 strains or lines available

References

• Original: J:148467 Chen YF, et al., Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. Genes Dev. 2009 May 15;23(10):1183-94
• All: 3 reference(s)