Cltrn^tm1Thu
Targeted Allele Detail

Summary

• Symbol: Cltrn^tm1Thu
• Name: collectrin, amino acid transport regulator; targeted mutation 1, Thu H Le
• MGI ID: MGI:3846424
• Synonyms: collectrin^-, NX-17^-
• Gene: Cltrn Location: ChrX:162873183-162901855 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Cltrn^tm1Thu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Most of exon 4 and all of exon 5 were replaced with a neomycin cassette. Gene inactivation was confirmed by a lack of immunohistochemical signal in hemizygous null kidney cortex. (J:148752)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cltrn Mutation: 9 strains or lines available

References

• Original: J:148752 Malakauskas SM, et al., Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. Am J Physiol Renal Physiol. 2007 Feb;292(2):F533-44
• All: 4 reference(s)