Tg(FCER1A)1Bhk
Transgene Detail

Summary

• Symbol: Tg(FCER1A)1Bhk
• Name: transgene insertion 1, Beverly H Koller
• MGI ID: MGI:3846551
• Synonyms: hFcepsilonR1alpha^- hFcepsilonR1alpha+, hFcepsilonR1alphaTg
• Transgene: Tg(FCER1A)1Bhk Location: unknown
• Alliance: Tg(FCER1A)1Bhk page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:113572
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FCER1A)1Bhk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCER1A (2205)

  Fcer1a

  (MGI:95494)

• Mutation details: The transgenic construct contains the entire human Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, (FCER1A), including 2.9kb of upstream sequence. The transgene was coinjected with a plasmid containing the hprt minigene. These constructs were transfected into ES65-154 (E14TG2a-165) embryonic stem (ES). (J:113572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

ES cells = ES65-154 (E14TG2a-165) cells

References

• Original: J:113572 Dombrowicz D, et al., Anaphylaxis mediated through a humanized high affinity IgE receptor. J Immunol. 1996 Aug 15;157(4):1645-51
• All: 9 reference(s)