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Fat4tm2Hmc
Targeted Allele Detail
Summary
Symbol: Fat4tm2Hmc
Name: FAT atypical cadherin 4; targeted mutation 2, Helen McNeill
MGI ID: MGI:3846574
Synonyms: Fat45A7
Gene: Fat4  Location: Chr3:38941089-39066134 bp, + strand  Genetic Position: Chr3, 18.72 cM
Alliance: Fat4tm2Hmc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138247
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. One allele is derived from line 2E11 in which targeting occured as expected, Fat4tm1Hmc . Insertion of the targeting vector in the 5A7 line induced a recombination of the Fat4 locus, resulting in this null allele. (J:138247)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fat4 Mutation:  224 strains or lines available
Notes
This mouse is no longer being maintained. However, the 5A7 ES cell line from which it was derived is still being kept by Dr. Helen McNeill.
References
Original:  J:138247 Saburi S, et al., Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory