Tlx2^{tm1.1(cre)Rpk}
Targeted Allele Detail

Summary

• Symbol: Tlx2^{tm1.1(cre)Rpk}
• Name: T cell leukemia, homeobox 2; targeted mutation 1.1, Raj P Kapur
• MGI ID: MGI:3846678
• Synonyms: Hox11L1-Cre
• Gene: Tlx2 Location: Chr6:83045306-83047206 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
• Alliance: Tlx2^{tm1.1(cre)Rpk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148830
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tlx2^{tm1.1(cre)Rpk} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tlx2 (MGI:1350935)

• Mutation details: Part of exon 1 downstream of the translation initiation site was replaced with cre and a floxed neo cassette. The cre cassette was spontaneously excised. (J:148830)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tlx2 (mouse) Summary of all recombinase alleles driven by Tlx2. Alliance mouse Tlx2 gene page

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx2 Mutation: 12 strains or lines available

References

• Original: J:148830 Kapur RP, et al., Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice. Pediatr Dev Pathol. 2005 Mar-Apr;8(2):148-61
• All: 2 reference(s)