Ptgs2^tm3Fun
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm3Fun
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 3, Colin D Funk
• MGI ID: MGI:3846762
• Synonyms: COX-2^Neo
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm3Fun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148699
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 9 via homologous recombination. Western blot analysis confirmed decreased protein expression in unstimulated and stimulated macrophages and endothelial cells from homozygous mice. (J:148699)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:148699 Seta F, et al., Renal and cardiovascular characterization of COX-2 knockdown mice. Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1751-60
• All: 3 reference(s)