Smurf1^tm1Wran
Targeted Allele Detail

Summary

• Symbol: Smurf1^tm1Wran
• Name: SMAD specific E3 ubiquitin protein ligase 1; targeted mutation 1, Jeffrey Wrana
• MGI ID: MGI:3846785
• Gene: Smurf1 Location: Chr5:144813305-144902657 bp, - strand Genetic Position: Chr5, 84.83 cM, cytoband G2
• Alliance: Smurf1^tm1Wran page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148693
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on heart extracts. (J:148693)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smurf1 Mutation: 55 strains or lines available

References

• Original: J:148693 Narimatsu M, et al., Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17;137(2):295-307
• All: 6 reference(s)