Sgk1^tm1.2Palm
Targeted Allele Detail

Summary

• Symbol: Sgk1^tm1.2Palm
• Name: serum/glucocorticoid regulated kinase 1; targeted mutation 1.2, Lawrence G Palmer
• MGI ID: MGI:3846797
• Gene: Sgk1 Location: Chr10:21758083-21875802 bp, + strand Genetic Position: Chr10, 9.83 cM, cytoband A3
• Alliance: Sgk1^tm1.2Palm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148648
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted into the BsaHI site in intron 1, and a loxP site and a FRT-flanked neomycin cassette was inserted into the XcmI site in intron 6. Mice carrying this allele were crossed with cre deleter mice to remove exons 2-6. Gene inactivation was confirmed by RT-PCR analysis of homozygous kidney extracts. (J:148648)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgk1 Mutation: 151 strains or lines available

References

• Original: J:148648 Fejes-Toth G, et al., Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1298-305
• All: 3 reference(s)