Stk4^tm1.1Kina
Targeted Allele Detail

Summary

• Symbol: Stk4^tm1.1Kina
• Name: serine/threonine kinase 4; targeted mutation 1.1, Tatsuo Kinashi
• MGI ID: MGI:3847089
• Gene: Stk4 Location: Chr2:163916033-163997444 bp, + strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Stk4^tm1.1Kina page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148791
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying the floxed Mst1^tm1Kina allele were crossed with a cre transgenic strain to excise the first exon of the locus from germline cells. Gene inactivation was confirmed by immunoblot analysis of spleen, thymus, brain and lung tissues. (J:148791)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk4 Mutation: 74 strains or lines available

References

• Original: J:148791 Katagiri K, et al., Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J. 2009 May 6;28(9):1319-31
• All: 3 reference(s)