Tg(SMN2*A111G)591Ahmb
Transgene Detail

Summary

• Symbol: Tg(SMN2*A111G)591Ahmb
• Name: transgene insertion 591, Arthur H M Burghes
• MGI ID: MGI:3847326
• Synonyms: A591, line 591, SMN(A111G), SMN(A11G)
• Transgene: Tg(SMN2*A111G)591Ahmb Location: unknown
• Alliance: Tg(SMN2*A111G)591Ahmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SMN2*A111G)591Ahmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: : A transgenic construct containing the SMN(A111G) missense mutation under the control of 4.1 kb SMN promoter was injected into fertilized FVB/N mouse eggs. Ten founder lines were obtained and line 588 was subsequently established. This line was found to have 5 copies of the transgene. (J:148541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:148541 Workman E, et al., A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet. 2009 Jun 15;18(12):2215-29
• All: 1 reference(s)