Egln1^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1Pec
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:3847435
• Synonyms: PHD2^-
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148719
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP flanked neo cassette replaced exon 2 of the gene. Absence of protein product was confirmed by western blot of homozygous embryos. (J:148719)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 22 strains or lines available

References

• Original: J:148719 Mazzone M, et al., Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009 Mar 6;136(5):839-51
• All: 16 reference(s)