Cavin3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Cavin3^{tm1(KOMP)Vlcg}
• Name: caveolae associated 3; targeted mutation 1, Velocigene
• MGI ID: MGI:3847505
• Gene: Cavin3 Location: Chr7:105129823-105131404 bp, - strand Genetic Position: Chr7, 55.87 cM, cytoband F1
• Alliance: Cavin3^{tm1(KOMP)Vlcg} page
• IMPC: Cavin3 gene page

Mutation origin

• Mutant Cell Lines: 11448A-A5, 11448A-A12, 11448A-C3, 11448A-C6, 11448A-D8
• Germline Transmission: Earliest citation of germline transmission: J:205741
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1369bp between positions 105129995-105131363 of Chromosome 7 (Build GRCm39). The cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the lung, heart, fat, skeletal muscle, brain and liver. (J:136110, J:205741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Cavin3 Mutation: 11 strains or lines available

Notes

Cell line 11448A-D8 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205741

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)