Lbn8b^SM/J
QTL Variant Detail

Summary

• QTL variant: Lbn8b^SM/J
• Name: long bones 8b; SM/J
• MGI ID: MGI:3847714
• QTL: Lbn8b Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:147462

Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.

Two novel bone length loci were identified on mouse Chromosome 9. Lbn8b (long bones 8b) mapped to 43 cM near rs3670195 and displays linkage to ulna (LPR=7.52) and tibia (LPR=3.88) lengths. Lbn8c (long bones 8c) is a single-trait QTL mapping to 61 cM near rs3723953. This QTL displays linkage to humerus length with LPR=5.45.

References

• Original: J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• All: 1 reference(s)