Lbn12a^SM/J
QTL Variant Detail

Summary

• QTL variant: Lbn12a^SM/J
• Name: long bones 12a; SM/J
• MGI ID: MGI:3847731
• QTL: Lbn12a Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:147462

Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.

Three separate bone length QTL were identified on mouse Chromosome 11. Lbn12a (long bones12a) mapped to 23 cM near rs6326787 in linkage to ulna (LPR=9.47) and tibia (LPR=7.19) lengths. Linkage to tibia length at Lbn12a is significantly greater in males compared to females. Lbn12b (long bones 12b) is a single-trait QTL for tibia length (LPR=8.15) mapping to 38 cM near rs3658906. Lbn12c (long bones 12c) mapped to 75 cM near rs3662930 and displays linkage to humerus (LPR=7.96) and ulna (LPR=5.39) lengths.

References

• Original: J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• All: 1 reference(s)