Bmp7^tm1.1Dgra
Targeted Allele Detail

Summary

• Symbol: Bmp7^tm1.1Dgra
• Name: bone morphogenetic protein 7; targeted mutation 1.1, Daniel Graf
• MGI ID: MGI:3847797
• Synonyms: Bmp7^fl, Bmp7^flx, Bmp7^flx(neo-)
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^tm1.1Dgra page

Abnormal caudal body formation in Bmp4^tm4Blh/Bmp4⁺ Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra Hoxa3^tm1(cre)Moon/Hoxa3⁺ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149134
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, frt mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:149134)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:149134 Zouvelou V, et al., Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol. 2009;53(4):597-603
• All: 17 reference(s)