Pink1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Lex
• Name: PTEN induced putative kinase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3847806
• Synonyms: Pink1^tm1Ncw
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148903
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An IRES-lacZ/neo cassette replaced most of exon 2, and all of exons 3-5 as well as the intervening intronic sequences. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of cortical neuron lysates. (J:148903)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:148903 Wood-Kaczmar A, et al., PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One. 2008;3(6):e2455
• All: 9 reference(s)