Tg(LRRK2)1Cjli
Transgene Detail

Summary

• Symbol: Tg(LRRK2)1Cjli
• Name: transgene insertion 1, Chenjian Li
• MGI ID: MGI:3847810
• Synonyms: BAC WT LRRK2, TG-WT-OX, WT-OX
• Transgene: Tg(LRRK2)1Cjli Location: unknown
• Alliance: Tg(LRRK2)1Cjli page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LRRK2)1Cjli expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: The human bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 188 kb BAC containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene with 29 kb upstream of the LRRK2 start codon and 42 kb downstream of the LRRK2 stop codon. Bioinformatics analysis predicted that no other genes are present in the BAC. This BAC was microinjected into fertilized FVB/NTac zygotes. (J:149135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149135 Li Y, et al., Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 2009 Jun 7;12(7):826-8
• All: 7 reference(s)