Bcl2l1^Plt20
Chemically induced Allele Detail

Summary

• Symbol: Bcl2l1^Plt20
• Name: BCL2-like 1; platelet 20
• MGI ID: MGI:3847887
• Synonyms: Bcl-X²⁰, Bcl-XL²⁰, Bcl-XL^Plt20, Bcl-X^Plt20
• Gene: Bcl2l1 Location: Chr2:152622588-152673648 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H1
• Alliance: Bcl2l1^Plt20 page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis caused an A-to-G transition that led to the substitution of cysteine for tyrosine at amino acid residue 15. The mutation shortened the 18 hour half-life of the wild-type protein to under 12 hours. This is considered a hypomorph allele. (J:149205)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2l1 Mutation: 104 strains or lines available

References

• Original: J:149205 Mason KD, et al., Programmed anuclear cell death delimits platelet life span. Cell. 2007 Mar 23;128(6):1173-86
• All: 6 reference(s)