Pidd1^tm1.1Anvi
Targeted Allele Detail

Summary

• Symbol: Pidd1^tm1.1Anvi
• Name: p53 induced death domain protein 1; targeted mutation 1.1, Andreas Villunger
• MGI ID: MGI:3847893
• Synonyms: pidd^-
• Gene: Pidd1 Location: Chr7:141018026-141023938 bp, - strand Genetic Position: Chr7, 86.79 cM
• Alliance: Pidd1^tm1.1Anvi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148929
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 3-15 of the gene were replaced by the open reading frame of beta-galactosidase followed by a loxP flanked neo cassette. The loxP flanked neo cassette was removed in vivo by cre-mediated deletion. RT-PCR analysis confirmed the absence of mRNA in thymocytes and MEFs. Absence of protein product was confirmed by western blot of thymocyte extracts derived from homozygous mice. (J:148929)

Generation of the Pidd1^tm1.1Anvi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pidd1 Mutation: 52 strains or lines available

References

• Original: J:148929 Manzl C, et al., Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol. 2009 Apr 20;185(2):291-303
• All: 7 reference(s)