Elavl1^tm1.2Dkon
Targeted Allele Detail

Summary

• Symbol: Elavl1^tm1.2Dkon
• Name: ELAV like RNA binding protein 1; targeted mutation 1.2, Dimitris L Kontoyiannis
• MGI ID: MGI:3847912
• Synonyms: HuR^-
• Gene: Elavl1 Location: Chr8:4335382-4375413 bp, - strand Genetic Position: Chr8, 2.0 cM
• Alliance: Elavl1^tm1.2Dkon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149149
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination of the floxed Elavl1^tm1Dkon allele results in removal of the ATG-containing second exon and the neo cassette. Gene inactivation was confirmed by a lack of protein in E11.5 extracts as determined by immunoblot analysis. (J:149149)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elavl1 Mutation: 43 strains or lines available

References

• Original: J:149149 Katsanou V, et al., The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009 May;29(10):2762-76
• All: 2 reference(s)