Tg(MMTV-NFKBIA*S32A*S36A)13Mka
Transgene Detail

Summary

• Symbol: Tg(MMTV-NFKBIA*S32A*S36A)13Mka
• Name: transgene insertion 13, Michael Karin
• MGI ID: MGI:3847925
• Synonyms: MMTV-Ikappabalpha^A32/36
• Transgene: Tg(MMTV-NFKBIA*S32A*S36A)13Mka Location: unknown
• Alliance: Tg(MMTV-NFKBIA*S32A*S36A)13Mka page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-NFKBIA*S32A*S36A)13Mka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKBIA (4792)

  Nfkbia

  (MGI:104741)

  Transgene codes for a protein with two serine to alanine mutations.

• Mutation details: This transgene consists of a HA-tagged human NFKBIA cDNA with Ser to Ala substitutions at positions 32 and 36 under the control of the MMTV promoter. (J:90978)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90978 Cao Y, et al., IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14;107(6):763-75
• All: 1 reference(s)