Timm23^{Gt(W023C08)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Timm23^{Gt(W023C08)Wrst}
• Name: translocase of inner mitochondrial membrane 23; gene trap W023C08, Wolfgang Wurst
• MGI ID: MGI:3848025
• Synonyms: Tim23^-
• Gene: Timm23 Location: Chr14:31902123-31923848 bp, - strand Genetic Position: Chr14, 19.4 cM
• Alliance: Timm23^{Gt(W023C08)Wrst} page

Mutation origin

• Mutant Cell Line: W023C08
• Germline Transmission: Earliest citation of germline transmission: J:149173
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pT1betageo
• Mutation details: The gene trap vector, containing a beta-geo cassette, inserted downstream of exon 6. The reduction in protein expression was confirmed by western blot analysis mitochondrial protein samples from heterozygous mice. (J:149173)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  W023C08	BZ690282 ; (MGI Seq Detail)	5' RACE	Chr14:31911100-31911200 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  27 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timm23 Mutation: 28 strains or lines available

References

• Original: J:149173 Ahting U, et al., Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta. 2009 May;1787(5):371-6
• All: 2 reference(s)