Akt3^tm1Nhy
Targeted Allele Detail

Summary

• Symbol: Akt3^tm1Nhy
• Name: thymoma viral proto-oncogene 3; targeted mutation 1, Nissim Hay
• MGI ID: MGI:3848061
• Gene: Akt3 Location: Chr1:176847639-177085769 bp, - strand Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
• Alliance: Akt3^tm1Nhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149156
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Five base pairs (GAGGA) that encode two glutamic acids (E114 and E115) in exon 4 were replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by RT-PCR on placenta extracts. (J:149156)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt3 Mutation: 42 strains or lines available

References

• Original: J:149156 Chen WS, et al., Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol. 2009 Jun;29(11):3151-62
• All: 4 reference(s)